What is LubriSynHA Pet & Equine?
With over 200 moveable or semi-movable joints in their bodies, dogs must have joints that move comfortably and freely.LubriSynHA provides the missing piece in joint health management:synovial fluid support.No other method provides the oral, natural hyaluronic acid (HA) that LubriSynHA Pet & Equine offers to cushion and lubricate the joint on a daily basis.
What is LubriSynHA Pet & Equine comprised of?
LubriSynHA is an all-natural, oral, liquid form of Hyaluronic Acid.The purified, high molecular weight hyaluronan in LubriSynHA is extracted from a microbial source. Other oral HA products are made from rooster combs or chicken cartilage. The microbial biofermentation results in a high molecular weight HA, and keeps it free from proteins, dermatan, chondroitin sulfate and other glycosaminoglycan contamination that may be found in other HA products.
Why is high molecular weight important?
Normal, healthy synovial fluid contains hyaluronan (HA) with a molecular weight of two to three million Daltons (MDa).Smaller molecular weight HA is not the same.As the molecular weight decreases, fluid viscosity decreases.Based on studies of intra-articular injections of HA in humans, the higher molecular weight HA molecules can relieve pain.HA at the higher molecular weight that matches native HA is associated with the beneficial roles that we expect in a healthy joint.Bigger is better!
Why is LubriSynHA Pet & Equine the best product for my pets?
Supplemental hyaluronan can increase synovial fluid viscosity.LubriSynHA is used to provide joint health support during treatment for osteoarthritis, osteochondrosis, rapid growth, exercise and the rigors of normal wear and tear.Elite AKC Obedience and Agility trainers are using LubriSynHA to support their canine partners during competition.LubriSynHA helps increase synovial fluid viscosity as an oral supplement.
How does LubriSynHA Pet & Equine compare to Adequan® Canine?
LubriSynHA Pet & Equine is an daily oral hyaluronan joint supplement.Adequan Canine is an injectable drug given by veterinarians to dogs to help improve joint function. Adequan is a polysulfated glycosaminoglycan that can increase production of joint hyaluronan.It is recommended by Novartis Animal Health to be given twice a week for four weeks; each injection has a duration of effect lasting about three days. (Novartis 2005)Pets can still be given LubriSynHA Pet & Equine while receiving Adequan.
Can you give too much LubriSynHA?
Our safety studies have shown that even at five times the recommended dose for 60 days, there were no adverse effects.Copies of our safety study analysis are available to you.
How much and how often should I give my dog LubriSynHA Pet & Equine?
The recommended daily oral dose for dogs is one teaspoon (5 ml) for dogs up to 30 pounds body weight.For dogs between 30 and 60 pounds, we suggest One and one-half teaspoons daily. For dogs between 60 and 100 pounds, two teaspoons. The amount may be doubled for hard-working dogs.
Is LubriSynHA Pet & Equine like Cosequin®?
No. LubriSynHA Pet & Equine is beneficial to the joint fluid. Cosequin is composed primarily of glucosamine and chondroitin sulfate and works on cartilage. (NutraMax Laboratories, Inc. 2005)
Will dogs like the taste?
LubriSynHA Pet & Equine is basically odorless and has a lightly sweet taste that most dogs love.
How long before I will see results?
Most animals will show an improvement in seven to fourteen days.
Is there proof that LubriSynHA Pet & Equine gets into the joint?
Studies of high molecular weight hyaluronan show that it begins to appear in tissues outside the intestinal tract in 30 minutes, and peaks between four and six hours post ingestion.As a daily supplement, LubriSynHA Pet & Equine provides a continual supply of hyaluronan to support the rapid turnover of synovial fluid hyaluronan.
Can LubriSynHA Pet & Equine go bad?
Yes.As with most liquid nutritional supplements, extreme hot or cold temperatures can cause breakdown, rendering the product ineffective.We recommend storing LubriSyn in a temperature range between 40 and 90 degrees Fahrenheit;It is advised that LubriSynHA not be frozen.LubriSyn is best used by the date indicated on the bottle:18 months is the recommended shelf life.
Are there any drugs in LubriSynHA Pet & Equine?
No. Hyaluronan is a naturally occurring substance found in the joints, skin and other tissues of all mammals. LubriSynHA Pet & Equine is made from a microbial source of hyaluronan along with a very small amount of sodium benzoate and potassium sorbate as protectants.
What is the difference between hyaluronan, sodium hyaluronate and hyaluronic acid?
These are three different names for the same compound.
Bucci, LR, and AA Turpin. “Will the real hyaluronan please stand up?” J of Appl Nutr 54, no. 1 (2004): 10-33.
Cantor, JO, and PP Nadkarni. “Hyaluronan: the Jekyll and Hyde molecule.” Inflamm Allergy Drug Targets 5, no. 4 (Dec 2006): 257-260.
Gotoh, S, et al. “Effects of the molecular weight of hyaluronic acid and its action mechanisms on experimental joint pain in rats.” Ann Rheum Dis 52, no. 11 (Nov 1993): 817-822.
Ishimaru, JI, N Ogi, S Mizuno, and AN Goss. “Quantitation of chondroitin-sulfates, disaccharides and hyaluronan in normal, early and advanced osteoarthritic sheep temporomandibular joints.” Osteoarthritis Cartilage 9, no. 4 (May 2001): 365-370.
Moreland, LW. “Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action.” Arthritis Res Ther 5, no. 2 (2003): 54-67.
Nakamura, K, et al. “High, but not low, molecular weight hyaluronan prevents T-cell-mediated liver injury by reducing proinflammatory cytokines in mice.” J Gastroenterol 39, no. 4 (2004): 346-354.
Novartis. Clinical Studies. 2005. http://www.adequancanine.us/vet/en/vet_clinicalStudies.shtml (accessed Feb 22, 2007).
NutraMax Laboratories, Inc. 2005. http://www.nutramaxlabs.com/Brochures/Cosequin Dog Brochure.pdf (accessed Feb 22, 2007).
Ohkawara, Y, G Tamura, T Iwasaki, A Tanaka, T Kikuchi, and K Shirato. “Activation and transforming growth factor-beta production in eosinophils by hyaluronan.” Am J Respir Cell Mol Biol 23, no. 4 (Oct 2000): 444-451.
Schauss, AG, LG Balogh, AG Polyak, RG Kiraly, and i GG Janok. “Absorption, distribution and excretion of 99mtechnetium labeled hyaluronan after single oral doses in rats and beagle dogs.” FASEB j 18, no. 4 (2004): A150-151.
Takahashi, T, et al. “A decreae in the molecular weight of hyaluronic acid in synovial fluid from patients with temporomandibular disorders.” J Oral Pathol Med 33, no. 4 (Apr 2004): 224-229.
Yeung, RW, RL Chow, Samman N, and K Chiu. “Short-term therapeutic outcome of intra-articular high molecular weight hyaluronic acid injection for non-reducing disc displacement of the temporomandibular joint.” Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102, no. 4 (Oct 2006): 453-461.